Physiological alterations during pregnancy: Impact on toxicokinetics
نویسندگان
چکیده
منابع مشابه
Alterations in physiology and anatomy during pregnancy.
Pregnant women undergo profound anatomical and physiological changes so that they can cope with the increased physical and metabolic demands of their pregnancies. The cardiovascular, respiratory, haematological, renal, gastrointestinal and endocrine systems all undergo important physiological alterations and adaptations needed to allow development of the fetus and to allow the mother and fetus ...
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an increased PEP/LVET, all more apparent in the supine than in the lateral position. These findings are consistent with impaired left ventricular performance and are probably due to decreased left ventricular preload resulting from diminished venous return secondary to inferior vena caval obstruction by the gravid uterus. In the postpartum period, the PEP/LVET remained elevated in both position...
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This study examined the role of pregnancy-induced changes in wakefulness (or non-chemoreflex) and central chemoreflex drives to breathe, acid-base balance and female sex hormones in the hyperventilation of human pregnancy. Thirty-five healthy women were studied in the third trimester (TM(3); 36.3+/-1.0 weeks gestation; mean+/-S.D.) and again 20.2+/-7.8 weeks post-partum (PP). An iso-oxic hypero...
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To the Editor: Metformin-associated lactic acidosis (MALA) following metformin overdose or reduced metformin clearance in the setting of acute kidney injury is associated with high mortality. For most severe cases, current guidelines recommend hemodialysis (HD) to correct acidosis and associated electrolyte abnormalities, although its effect on metformin removal is considered uncertain. We repo...
متن کاملImpact of zinc supplementation during pregnancy on the anthropometric indices of the newborns
Background: Nutritional status of pregnant mothers is one of the key factors in fetal growth. Micronutrients including Zinc lead to various biological consequences on mother and fetus. We therefore investigated the effect of supplemental zinc sulfate during pregnancy on the newborns weight, height and head circumference. Methods: Using a double-blinded controlled clinical trial, 465 pregnant ...
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ژورنال
عنوان ژورنال: Fundamental and Applied Toxicology
سال: 1991
ISSN: 0272-0590
DOI: 10.1016/0272-0590(91)90103-b